Medicinal Drug with Activity against Gram Positive Bacteria, Mycobacteria and Fungi

摘要

A medicinal drug is provided with activity against gram positive bacteria, mycobacteria and fungi characterized in that it is a compound of the class of pyrimidine derivatives of salicylic aldehyde and perhydropyrimidine-2,4,6-triones selected from a group consisting of tautomeric forms, salt forms, and a cyclic form of pyrylium salts, and with the general formula:;;where X1, X3 are selected from the group containing: H, halogen; NO2;
X2, X4 are selected from the group containing: H, halogen;Z is selected from the group containing: O, NNH2, NOH, perhydropyrimidine-5-ylidene-2,4.6-trione, perhydropyrimidine-5-ylidene-2,4.6-trione, substituted at the nitrogen atom with alkyl, aryl or aralkyl group;Y is selected from the group containing: H, Na, Li, K.

Further, methods for treating infections, tonsillitis, pneumonia, or wound infections caused by Gram-positive bacteria, mycobacteria and fungi are provided using a therapeutically effective amount of the compound.

主权项

1. Medicinal drug with activity against gram positive bacteria, mycobacteria and fungi characterized in that it is a compound of the class of pyrimidine derivatives of salicylic aldehyde and perhydropyrimidine-2,4,6-triones selected from a group consisting of tautomeric forms, salt forms, and a cyclic form of pyrylium salts, and with the general formula: where X1, X3 are selected from the group containing: H, halogen; NO2;
X2, X4 are selected from the group containing: H, halogen;Z is selected from the group containing: O, NNH2, NOH, perhydropyrimidine-5-ylidene-2,4.6-trione, perhydropyrimidine-5-ylidene-2,4.6-trione, substituted at the nitrogen atom with alkyl, aryl or aralkyl group;Y is selected from the group containing: H, Na, Li, K.