发明名称 3-(1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-1H-PYRAZOLO[4,3-B]PYRIDINES AND THERAPEUTIC USES THEREOF
摘要 4-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a 4-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
申请公布号 WO2017024004(A1) 申请公布日期 2017.02.09
申请号 WO2016US45296 申请日期 2016.08.03
申请人 SAMUMED, LLC. 发明人 KC, Sunil Kumar;WALLACE, David Mark;CAO, Jianguo;CHIRUTA, Chandramouli;HOOD, John
分类号 A61K31/4162;A61K31/4188;A61K31/437 主分类号 A61K31/4162
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