BIOSENSOR USING MAGNETIC PARTICLES FOR PATHOGEN DETECTION

摘要

There is provided a biosensor for detecting pathogens in a sample. The detection is based on colorimetry. The biosensor comprises one or more particle supports and a magnetic material attached to a planar support. The biosensor embodies magnetic particles that are functionalized using a chemical substrate specific to the pathogens to be detected. The sensor may allow for a simultaneous detection of a plurality of pathogens in the sample. Also, the sensor may be disposable. Moreover, the sensor may be integrated in a portable detection device.

主权项

1. A biosensor for detecting a pathogen in a sample, comprising:
a planar support; a particle support attached to a surface of the planar support, the particle support being of a first color; a magnetic material attached to the other surface of the planar support and spaced apart from the location of the particle support; and a plurality of magnetic particles of a second color different from the first color, each particle being attached to the particle support through a chemical substrate specific to the pathogen to be detected, a first end of the chemical substrate being attached to the magnetic particle and a second end of the chemical substrate being attached to particle support, such that a visual inspection of the particle support reveals only the second color, the first color being masked by the magnetic particles,wherein upon contacting the particle support with the sample, a reaction occurs between the chemical substrate and the pathogen which results in the magnetic particle being released from the particle support revealing the second color, and the released magnetic particle is attracted by the magnetic material.