TARGETED THERAPY TO RESTORE RADIOACTIVE IODINE TRANSPORT IN THYROID CANCER

摘要

The invention includes method, pharmaceutical compositions and uses thereof for treating patients with Papillary Thyroid Carcinoma (PTC) using a Platelet Derived Growth Factor Receptor Alpha (PDGFRA) inhibitor. The PDGFRA inhibitor is preferably an antibody specific to PDGFRA and causes an increase in the sensitivity level of PTC cells to radioiodine treatment. Moreover, the antibody can be used in combination with other PDGFRA inhibitors such as tyrosine kinase inhibitors and RNA interference molecules.

主权项

1. A method for treating a patient with papillary thyroid carcinoma comprising:
administering a therapeutically effective amount of at least one PDGFRA inhibitor, or a pharmaceutically acceptable salt thereof, to a patient with papillary thyroid carcinoma, wherein the administering of the PDGFRA inhibitor treats or reduces the severity of papillary thyroid carcinoma symptoms.