METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS FOR CONDITIONS ASSOCIATED WITH MICROBIOME TAXONOMIC FEATURES

摘要

A method for at least one of characterizing, diagnosing, and treating a condition associated with microbiome taxonomic features in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

主权项

1. A method for characterizing a gastrointestinal or gastroesophageal reflux condition, the method comprising:
at a sample handling network, receiving an aggregate set of samples from a population of subjects; at a computing system in communication with the sample handling network, generating a microbiome composition dataset and a microbiome functional feature dataset for the population of subjects upon processing content of each of the aggregate set of samples, wherein processing content of each of the aggregate set of samples comprises processing nucleic content with a fragmentation operation, a multiplexed amplification operation using a set of primers, and a sequencing analysis operation; at the computing system, receiving a supplementary dataset that is informative of gastrointestinal reflux condition presence within the population of subjects; at the computing system, transforming the supplementary dataset and features extracted from at least one of the microbiome composition and the microbiome functional feature datasets into a characterization model of the gastrointestinal reflux condition; and based upon the characterization model, generating a therapy model configured to improve a health state of an individual diagnosed with the gastrointestinal reflux condition by the characterization model.