| 发明名称 |
FC-REGION VARIANTS WITH MODIFIED FCRN-BINDING PROPERTIES |
| 摘要 |
Herein is reported a polypeptide comprising a first polypeptide and a second polypeptide each comprising in N-terminal to C-terminal direction at least a portion of an immunoglobulin hinge region, which comprises one or more cysteine residues, an immunoglobulin CH2-domain and an immunoglobulin CH3-domain, wherein
i) the first and the second polypeptide comprise the mutations H310A, H433A and Y436A, orii) the first and the second polypeptide comprise the mutations L251D, L314D and L432D, oriii) the first and the second polypeptide comprise the mutations L251S, L314S and L432S. |
| 申请公布号 |
US2017037121(A1) |
申请公布日期 |
2017.02.09 |
| 申请号 |
US201615210218 |
申请日期 |
2016.07.14 |
| 申请人 |
Hoffmann-La Roche Inc. |
发明人 |
Schlothauer Tilman |
| 分类号 |
C07K16/22 |
主分类号 |
C07K16/22 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A polypeptide comprising
a first polypeptide and a second polypeptide each comprising in N-terminal to C-terminal direction at least a portion of an immunoglobulin hinge region, which comprises one or more cysteine residues, an immunoglobulin CH2-domain and an immunoglobulin CH3-domain, wherein
i) the first and the second polypeptide comprise the mutations H310A, H433A and Y436A, orii) the first and the second polypeptide comprise the mutations L251D, L314D and L432D, oriii) the first and the second polypeptide comprise the mutations L251S, L314S and L432S. |
| 地址 |
Little Falls NJ US |
