ORGANIC COMPOUNDS

摘要

The invention relates to particular substituted heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving 5-HT2A receptor, serotonin transporter (SERT) and/or pathways involving dopamine D1/D2 receptor signaling systems, and/or the treatment of residual symptoms.

主权项

1. A compound of formula I: wherein: X is N(H), N(R5) or 0; R5 is C1-6 alkyl, optionally substituted with D; R3 and R4 are each independently H or D; R6 is H or D; R1 is H, or
C1-6 alkyl, optionally substituted with D, or a pharmaceutically acceptable and physiologically labile moiety,wherein D is deuterium, and provided that at least one of R1, R2, R3, R4, R5, or R6 includes at least one D; in free or salt form.