| 主权项 |
1. An isolated antagonistic antibody or an antigen binding portion thereof specifically binding human CD154 of SEQ ID NO: 1, comprising a heavy chain complementarity determining region (HCDR) 1 of SEQ ID NO: 17 (SYGIS), a HCDR2 of SEQ ID NO: 23 (WISPIFGNTNYAQKFQG) and a HCDR3 of SEQ ID NO: 30 (SRYYGDLDY), wherein optionally
a) the HCDR1 residue S1 is mutated to A, C, D, E, G, I, K, L, M, N, Q, R, T or V; b) the HCDR1 residue I4 is mutated to M, L or V; c) the HCDR1 residue S5 is mutated to A; d) the HCDR2 residue S3 is mutated to A, T or V; e) the HCDR2 residue P4 is mutated to V, T, L Q or E; f) the HCDR2 residue N8 is mutated to A, C, D, E, F, G, H, I, K, L, M, Q, R, S, T, V, W or Y; g) the HCDR2 residue T9 is mutated to A, C, D, E, F, G, H, I, K, L, M, Q, R, S, T, V, W or Y; h) the HCDR2 residue N10 is mutated to A, C, D, E, F, G, H, I, K, L, M, Q, R, S, T, V, W or Y; i) the HCDR3 residue S1 is mutated to A or M; j) the HCDR3 residue R2 is mutated to A, S, Q or K; and k) the HCDR3 residue L7 is mutated to M. |
