| 摘要 |
The present invention relates to a process for the preparation of a solid form of ivabradine hydrochloride by reduction of Compound 2 or a salt thereof in an aqueous solvent followed by extraction of ivabradine wherein the extraction comprises the steps of: 1) adding a water immiscible solvent 2) separating the layers 3) washing the water immiscible solvent layer with an amount of an acidic aqueous solution sufficient to obtain a molar ratio ivabradine to acid between 1:0.001 and 1:0.2 |
