| 发明名称 |
COMPOSITIONS AND METHODS FOR TISSUE REPAIR |
| 摘要 |
The present invention provides compositions and methods for targeting an extracellular matrix derived (EMD) peptide predominantly to an injured tissue, as opposed to an uninjured tissue in vivo. The targeted EMD peptide facilitates the repair and/or regeneration of the injured tissue by providing a surface for cells to attach and grow, thereby facilitating the repair and/or regeneration of the injured tissue. |
| 申请公布号 |
US2017035902(A1) |
申请公布日期 |
2017.02.09 |
| 申请号 |
US201615299865 |
申请日期 |
2016.10.21 |
| 申请人 |
TransTarget, Inc. ;The Regents of the University of California |
发明人 |
Lee Randall J.;Mihardja Shirley;Huang Manley;Larrick James W. |
| 分类号 |
A61K47/48;C07K7/08 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition for repair of an injured tissue, the composition comprising an injury-associated antigen-specific binding component conjugated to an extracellular matrix derived (EMD) peptide,
wherein the injury-associated antigen-specific binding component comprising a molecule that specifically binds an antigen expressed following tissue injury, and wherein the EMD peptide is a peptide or a concatamer of a peptide that ranges in length from about 8 amino acid residues to about 100 amino acid residues, and exhibits the ability to: (i) activate cells; (ii) attach cells; and (iii) exhibits a chemotropic property. |
| 地址 |
Burlingame CA US |
