| 主权项 |
1. A compound of formula I shown below: wherein: A1 is selected from N or CR1, A2 is selected from N or CR2, with the proviso that only one of A1 or A2 can be N; R1 and R2 are each independently selected from hydrogen, fluoro, chloro, cyano, (1-2C)alkyl, (1-2C)alkoxy, (1-2C)haloalkyl or (1-2C)haloalkoxy; R4 is selected from hydrogen, fluoro, chloro, bromo, iodo, CF3, OCF3, cyano, NO2, (1-4C)alkyl, (1-4C)alkoxy, or a group of the formula:
W—X—Y—Z wherein W is absent or (1-3C)alkylene; X is —O— or —N(Ra)—, wherein Ra is selected from hydrogen or (1-2C)alkyl; Y is absent or a (1-3C)alkylene; Z is hydrogen, (1-6C)alkyl or (3-6C)cycloalkyl; and wherein any alkylene, alkyl or cycloalkyl group present in a R4 substituent group is optionally further substituted by one or more substituent groups independently selected from halo, hydroxy, NRbRc, (1-2C)alkoxy, (1-2C)haloalkyl or (1-2C)haloalkoxy, and wherein Rb and Rc are each independently selected from hydrogen or (1-3C)alkyl; Q is a group of formula II: wherein A4a and A4b are each independently selected from N or CR9, wherein each R9 present is independently selected from hydrogen, halo, cyano, nitro, hydroxy, NRdRe, (1-3C)alkyl, (1-3C)alkoxy, 5 or 6-membered heteroaryl, or 5 or 6 membered heterocyclyl; wherein Rd and Re are each independently selected from hydrogen or (1-3C)alkyl; and wherein any (1-3C)alkyl, (1-3C)alkoxy, 5 or 6-membered heteroaryl, or 5 or 6 membered heterocyclyl group present in a R9 substituent group is optionally substituted by one or more substituents selected from halo, cyano, nitro, hydroxy, NRfRg or (1-3C)alkoxy, wherein Rf and Rg are each independently selected from hydrogen or (1-3C)alkyl; A4c is N or CR10; R10 is selected from hydrogen, halo, amino, cyano, nitro, hydroxy or a group
W1—X1—Y1—X4—Z1 wherein W1 is absent or a linker group of the formula —[CRhRi]p— in which p is an integer selected from 1, 2, 3 or 4, and Rh and Ri are each independently selected from hydrogen or (1-2C)alkyl; X1 is absent or —O—, —C(O)—, —C(O)O—, —OC(O)—, —CH(OR)—, —N(Rj)—, —N(Rj)—C(O)—, —N(Rj)—C(O)O—, —C(O)—N(Rj)—, —N(Rj)C(O)N(Rj)—, —S—, —SO—, —SO2—, —S(O)2N(Rj)—, or —N(Rj)SO2—, wherein Rj is selected from hydrogen or methyl; Y1 is absent or a linker group of the formula —[CRkRl]q— in which q is an integer selected from 1, 2, 3 or 4, and Rk and Rl are each independently selected from hydrogen or (1-2C)alkyl; X4 is absent or —O—, —C(O)—, —C(O)O—, —OC(O)—, —CH(OR)—, —N(Rj)—, —N(Rj)—C(O)—, —N(Rj)—C(O)O—, —C(O)—N(Rj)—, —N(Rj)C(O)N(Rj)—, —S—, —SO—, —SO2—, —S(O)2N(Rj)—, or —N(Rj)SO2— wherein Rj is selected from hydrogen or methyl; and Z1 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, aryl, (3-6C)cycloalkyl, (3-6C)cycloalkenyl, heteroaryl or heterocyclyl; and wherein Z1 is optionally further substituted by one or more substituent groups independently selected from oxo, halo, cyano, nitro, hydroxy, carboxy, NRmRn, (1-4C)alkoxy, (1-4C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl-(1-3C)alkyl, (1-4C)alkanoyl, (1-4C)alkylsulphonyl, aryl, aryloxy, heterocyclyl, heterocyclyloxy, heterocyclyl-(1-2C)alkyl, heteroaryl, heteroaryloxy, heteroaryl-(1-2C)alkyl, C(O)NRmRn, NRmC(O)Rn, NRmS(O)2Rn and S(O)2NRmRn; wherein Rm and Rn are each independently selected from hydrogen, (1-4C)alkyl or (3-6C)cycloalkyl or (3-6C)cycloalkyl(1-2C)alkyl; or Rm and Rn can be linked such that, together with the nitrogen atom to which they are attached, they form a 4-6 membered heterocyclic ring; and wherein any alkyl, aryl, heterocyclyl or heteroaryl group present in a substituent group on Z1 is optionally further substituted by halo, cyano, nitro, hydroxy, carboxy, NRoRp, (1-2C)alkoxy, or (1-2C)alkyl; wherein Ro and Rp are selected from hydrogen or (1-2C)alkyl; with the proviso that R10 is only hydrogen, halo or t-butyl when at least one of A4a and A4b is N or CR9 in which R9 is a substituent as defined above other than hydrogen; or Q is a group of formula III: wherein A5 is selected from N or CR5, where R5 is selected from hydrogen, halo, cyano, nitro, hydroxy, NRqRu, (1-3C)alkyl, (1-3C)alkoxy, 5 or 6-membered heteroaryl, or 5 or 6 membered heterocyclyl; wherein Rq and Ru are each independently selected from hydrogen or (1-3C)alkyl, and wherein any (1-3C)alkyl, (1-3C)alkoxy, 5 or 6-membered heteroaryl, or 5 or 6 membered heterocyclyl group present in a R5 substituent group is optionally substituted by one or more substituents selected from halo, cyano, nitro, hydroxy, NRvRw, or (1-3C)alkoxy, wherein Rv and Rw are each independently selected from hydrogen or (1-3C)alkyl; Ring A is: a fused phenyl ring; a fused 5 or 6 membered carbocyclic ring; a fused 5 or 6 membered heteroaryl ring comprising one or two heteroatoms independently from N, S or O; or a fused 5, 6 or 7-membered heterocyclic ring comprising one or two heteroatoms independently from N, S or O; A6 is selected from N, O, S, S(O), S(O)2, CR6, C(R6)2, NR60, where R6 is selected from hydrogen, oxo, fluoro, chloro, (1-2C)alkyl, (1-2C)alkoxy, (1-2C)haloalkoxy or (1-2C)haloalkyl and R60 is hydrogen, —O—, (1-6C)alkyl, —C(O)—R61, —C(O)O—R61, or —C(O)N(R62)R61, wherein R61 is selected from hydrogen, (1-6C)alkyl, (3-6C)cycloalkyl, aryl, heteroaryl or heterocyclyl and R62 is selected from hydrogen or (1-3C)alkyl; A7 is selected from N, O, CR7, S, S(O), S(O)2, C(R7)2, NR70, where R70 is hydrogen, —O—, (1-6C)alkyl, —C(O)—R71, —C(O)O—R71, or —C(O)N(R72)R71, wherein R71 is selected from hydrogen, (1-6C)alkyl, (3-6C)cycloalkyl, aryl, heteroaryl or heterocyclyl and R72 is selected from hydrogen or (1-3C)alkyl; m is 0, 1 or 2; R7 and R11 are each independently halo, cyano, oxo, or a group
W2—X2—Y2—X3—Z2 wherein W2 is absent or a linker group of the formula —[CRxRy]r— in which r is an integer selected from 1, 2, 3 or 4, and Rx and Ry are each independently selected from hydrogen or (1-2C)alkyl; X2 is absent, —O—, —C(O)—, —C(O)O—, —OC(O)—, —CH(OR)—, —N(Rj)—, —N(Rz)—C(O)—, —N(Rz)—C(O)O—, —C(O)—N(Rz)—, —N(Rz)C(O)N(Rz)—, —S—, —SO—, —SO2—, —S(O)2N(Rj)—, or —N(Rz)SO2, wherein Rz is selected from hydrogen or methyl; Y2 is absent or a linker group of the formula —[CRaaRbb]s— in which s is an integer selected from 1, 2, 3 or 4, and Raa and Rbb are each independently selected from hydrogen or (1-2C)alkyl; X3 is absent, —O—, —C(O)—, —C(O)O—, —OC(O)—, —CH(ORcc)—, —N(Rcc)—, —N(Rcc)—C(O)—, —N(Rcc)—C(O)O—, —C(O)—N(Rcc)—, —N(Rcc)C(O)N(Rcc)—, —S—, —SO—, —SO2—, —S(O)2N(Rcc)—, or —N(Rcc)SO2, wherein Rcc is selected from hydrogen or methyl; and Z2 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, aryl, (3-6C)cycloalkyl, (3-6C)cycloalkenyl, heteroaryl, or heterocyclyl, and wherein Z2 is optionally further substituted by one or more substituent groups independently selected from oxo, halo, cyano, nitro, hydroxy, carboxy, NRddRee, (1-4C)alkoxy, (1-4C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl-(1-3C)alkyl, (1-4C)alkanoyl, (1-4C)alkylsulphonyl, aryl, aryloxy, heterocyclyl, heterocyclyloxy, heterocyclyl-(1-2C)alkyl, heteroaryl, heteroaryloxy, heteroaryl-(1-2C)alkyl, C(O)NRddRee, NRddC(O)Ree, NRddSO2Ree and SO2NRddRee; wherein Rdd and Ree are each independently selected from hydrogen, (1-4C)alkyl, (3-6C)cycloalkyl or (3-6C)cycloalkyl(1-2C)alkyl; or Rdd and Ree can be linked such that, together with the nitrogen atom to which they are attached, they form a 4-6 membered heterocyclic ring; and wherein any alkyl, aryl, heterocyclyl or heteroaryl group present in a substituent group on Z2 is optionally further substituted by halo, cyano, nitro, hydroxy, carboxy, NRffRgg, (1-2C)alkoxy, or (1-2C)alkyl; wherein Rff and Rgg are selected from hydrogen or (1-2C)alkyl; with the proviso that when R7 is hydrogen (i.e. when W2, X2, Y2, and X3 are absent and Z2 is hydrogen) then ring A is not a fused dioxane ring; and when A1 and A2 are both CH and R4 is H, Q is not pyrid-4-yl. or a pharmaceutically acceptable salt or solvate thereof. |
