Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppresses the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.
申请公布号
EP3126398(A1)
申请公布日期
2017.02.08
申请号
EP20150759030
申请日期
2015.03.02
申请人
Academia Sinica;Kaohsiung Medical University;Roffler, Steven R.
发明人
ROFFLER, Steven R.;CHENG, Tian-Lu;KAO, Chien-Han;CHEN, Bing-Mae;SU, Yu-Cheng;TUNG, Hsin-Yi;CHUANG, Kuo-Hsiang