| 摘要 |
A method of identifying whether a subject having a B-cell disease is suitable to be treated with intravenous immunoglobulin (IVIg) or in need of treatment with IVIg. The method comprising detecting the presence or absence of a monoclonal immunoglobulin associated with the B-cell disease wherein if the monoclonal immunoglobulin is IgA, IgD, IgM, light chain only, the B-cell disease is non-secretory multiple myeloma (MM) or if the concentration of total IgG is below a pre-determined amount in a sample from the subject, the patient is suitable to be treated with IVIg or if the amount of polyclonal IgG is below a predetermined amount, the patient is in need of treatment with IVIg. Also claimed is a method of monitoring IVIg levels in a subject comprising monitoring the IgGλ lambda to IgGκ kappa ratio or the concentration of IgGλ lambda or IgGκ kappa in a subject. |
