Human monoclonal antibody

摘要

The invention provides a method for the prophylaxis, improvement, or treatment of inflammatory bowel disease, multiple sclerosis, and psoriasis by administering to a subject an effective amount of an isolated anti-human CD81 antibody capable of binding to a peptide region consisting of the amino acid sequence of amino acid numbers 80 to 175 of SEQ ID NO:22.

主权项

1. A method for the improvement or treatment of a disease selected from inflammatory bowel disease, multiple sclerosis and psoriasis, comprising administering to a subject an effective amount of a pharmaceutical composition comprising an isolated anti-human CD81 antibody, wherein the isolated anti-human CD81 antibody comprises all 6 CDRs described in any one of the following groups 1to 24:
Group 1 (a-1) a CDR comprising the amino acid sequence shown in SEQ ID NO:1, (b-1) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-1) a CDR comprising the amino acid sequence shown in SEQ ID NO:3, (d-1) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-1) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (f-1) a CDR comprising the amino acid sequence shown in SEQ ID NO:6 Group 2 (a-2) a CDR comprising the amino acid sequence shown in SEQ ID NO:1, (b-2) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-2) a CDR comprising the amino acid sequence shown in SEQ ID NO:37, (d-2) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-2) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (f-2) a CDR comprising the amino acid sequence shown in SEQ ID NO:6 Group 3 (a-3) a CDR comprising the amino acid sequence shown in SEQ ID NO:1, (b-3) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-3) a CDR comprising the amino acid sequence shown in SEQ ID NO:40, (d-3) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-3) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (f-3) a CDR comprising the amino acid sequence shown in SEQ ID NO:6 Group 4 (a-4) a CDR comprising the amino acid sequence shown in SEQ ID NO:1, (b-4) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-4) a CDR comprising the amino acid sequence shown in SEQ ID NO:43, (d-4) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-4) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (f-4) a CDR comprising the amino acid sequence shown in SEQ ID NO:6 Group 5 (a-5) a CDR comprising the amino acid sequence shown in SEQ ID NO:1, (b-5) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-5) a CDR comprising the amino acid sequence shown in SEQ ID NO:46, (d-5) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-5) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (t-5) a CDR comprising the amino acid sequence shown in SEQ ID NO:6 Group 6 (a-6) a CDR comprising the amino acid sequence shown in SEQ ID NO:1, (b-6) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-6) a CDR comprising the amino acid sequence shown in SEQ ID NO:49, (d-6) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-6) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (f-6) a CDR comprising the amino acid sequence shown in SEQ ID NO:6 Group 7 (a-7) a CDR comprising the amino acid sequence shown in SEQ ID NO:1, (b-7) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-7) a CDR comprising the amino acid sequence shown in SEQ ID NO:52, (d-7) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-7) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (f-7) a CDR comprising the amino acid sequence shown in SEQ ID NO:6 Group 8 (a-8) a CDR comprising the amino acid sequence shown in SEQ ID NO:1, (b-8) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-8) a CDR comprising the amino acid sequence shown in SEQ ID NO:43, (d-8) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-8) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (f-8) a CDR comprising the amino acid sequence shown in SEQ ID NO:55 Group 9 (a-9) a CDR comprising the amino acid sequence shown in SEQ ID NO:60, (b-9) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-9) a CDR comprising the amino acid sequence shown in SEQ ID NO:3, (d-9) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-9) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (f-9) a CDR comprising the amino acid sequence shown in SEQ ID NO:61 Group 10 (a-10) a CDR comprising the amino acid sequence shown in SEQ ID NO:1, (b-10) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-10) a CDR comprising the amino acid sequence shown in SEQ ID NO:66, (d-10) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-10) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (f-10) a CDR comprising the amino acid sequence shown in SEQ ID NO:6 Group 11 (a-11) a CDR comprising the amino acid sequence shown in SEQ ID NO:1, (b-11) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-11) a CDR comprising the amino acid sequence shown in SEQ ID NO:3, (d-11) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-11) a CDR comprising the amino acid sequence shown in SEQ ID NO:69, and (f-11) a CDR comprising the amino acid sequence shown in SEQ ID NO:70 Group 12 (a-12) a CDR comprising the amino acid sequence shown in SEQ ID NO:60, (b-12) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-12) a CDR comprising the amino acid sequence shown in SEQ ID NO:66, (d-12) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-12) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (f-12) a CDR comprising the amino acid sequence shown in SEQ ID NO:6 Group 13 (a-13) a CDR comprising the amino acid sequence shown in SEQ ID NO:1, (b-13) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-13) a CDR comprising the amino acid sequence shown in SEQ ID NO:3, (d-13) a CDR comprising the amino acid sequence shown in SEQ ID NO:77, (e-13) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (f-13) a CDR comprising the amino acid sequence shown in SEQ ID NO:6 Group 14 (a-14) a CDR comprising the amino acid sequence shown in SEQ ID NO:80, (b-14) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-14) a CDR comprising the amino acid sequence shown in SEQ ID NO:3, (d-14) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-14) a CDR comprising the amino acid sequence shown in SEQ ID NO:81, and (f-14) a CDR comprising the amino acid sequence shown in SEQ ID NO:6 Group 15 (a-15) a CDR comprising the amino acid sequence shown in SEQ ID NO:1, (b-15) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-15) a CDR comprising the amino acid sequence shown in SEQ ID NO:66, (d-15) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-15) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (f-15) a CDR comprising the amino acid sequence shown in SEQ ID NO:6 Group 16 (a-16) a CDR comprising the amino acid sequence shown in SEQ ID NO:1, (b-16) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-16) a CDR comprising the amino acid sequence shown in SEQ ID NO:90, (d-16) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-16) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (f-16) a CDR comprising the amino acid sequence shown in SEQ ID NO:6 Group 17 (a-17) a CDR comprising the amino acid sequence shown in SEQ ID NO:1, (b-17) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-17) a CDR comprising the amino acid sequence shown in SEQ ID NO:52, (d-17) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-17) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (f-17) a CDR comprising the amino acid sequence shown in SEQ ID NO:93 Group 18 (a-18) a CDR comprising the amino acid sequence shown in SEQ ID NO:98, (b-18) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-18) a CDR comprising the amino acid sequence shown in SEQ ID NO:3, (d-18) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-18) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (f-18) a CDR comprising the amino acid sequence shown in SEQ ID NO:99 Group 19 (a-19) a CDR comprising the amino acid sequence shown in SEQ ID NO:60, (b-19) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-19) a CDR comprising the amino acid sequence shown in SEQ ID NO:3, (d-19) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-19) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (f-19) a CDR comprising the amino acid sequence shown in SEQ ID NO:99 Group 20 (a-20) a CDR comprising the amino acid sequence shown in SEQ ID NO:1, (b-20) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-20) a CDR comprising the amino acid sequence shown in SEQ ID NO:90, (d-20) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-20) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (f-20) a CDR comprising the amino acid sequence shown in SEQ ID NO:6 Group 21 (a-21) a CDR comprising the amino acid sequence shown in SEQ ID NO:1, (b-21) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-21) a CDR comprising the amino acid sequence shown in SEQ ID NO:3, (d-21) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-21) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (f-21) a CDR comprising the amino acid sequence shown in SEQ ID NO:55 Group 22 (a-22) a CDR comprising the amino acid sequence shown in SEQ ID NO:1, (b-22) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-22) a CDR comprising the amino acid sequence shown in SEQ ID NO:66, (d-22) a CDR comprising the amino acid sequence shown in SEQ ID NO:110, (e-22) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (f-22) a CDR comprising the amino acid sequence shown in SEQ ID NO:6 Group 23 (a-23) a CDR comprising the amino acid sequence shown in SEQ ID NO:1, (b-23) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-23) a CDR comprising the amino acid sequence shown in SEQ ID NO:3, (d-23) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-23) a CDR comprising the amino acid sequence shown in SEQ ID NO:5, and (f-23) a CDR comprising the amino acid sequence shown in SEQ ID NO:115 Group 24 (a-24) a CDR comprising the amino acid sequence shown in SEQ ID NO:1, (b-24) a CDR comprising the amino acid sequence shown in SEQ ID NO:2, (c-24) a CDR comprising the amino acid sequence shown in SEQ ID NO:90, (d-24) a CDR comprising the amino acid sequence shown in SEQ ID NO:4, (e-24) a CDR comprising the amino acid sequence shown in SEQ ID NO:120, and (f-24) a CDR comprising the amino acid sequence shown in SEQ ID NO:6.