| 发明名称 | Anti-B7-H4 antibodies and immunoconjugates | ||
| 摘要 | The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same. | ||
| 申请公布号 | US9562099(B2) | 申请公布日期 | 2017.02.07 |
| 申请号 | US201414207878 | 申请日期 | 2014.03.13 |
| 申请人 | Genentech, Inc. | 发明人 | Leong Steven R.;Polson Andrew;Polakis Paul;Wu Yan;Liang Wei-Ching;Firestein Ron |
| 分类号 | C07K16/28;A61K47/48;A61K45/06;G01N33/574;A61K51/10;A61K39/395;A61K39/00 | 主分类号 | C07K16/28 |
| 代理机构 | McNeill Baur PLLC | 代理人 | McNeill Baur PLLC |
| 主权项 | 1. An isolated antibody that binds to B7-H4, wherein the antibody binds to an epitope within all or a portion of the B7-H4 Ig-V and Ig-C domains (amino acids 29-250 of SEQ ID NO: 73) and binds to B7-H4 with an affinity of ≦50 nM, wherein the antibody comprises: (a)(i) HVR-H3 comprising the amino acid sequence of SEQ ID NO: 31, (ii) HVR-L3 comprising the amino acid sequence of SEQ ID NO: 34, and (iii) HVR-H2 comprising the amino acid sequence of SEQ ID NO: 30; or (b)(i) HVR-H3 comprising the amino acid sequence of SEQ ID NO: 60, (ii) HVR-L3 comprising the amino acid sequence of SEQ ID NO: 63, and (iii) HVR-H2 comprising the amino acid sequence of SEQ ID NO: 59. | ||
| 地址 | South San Francisco CA US | ||