Injectable fillers for aesthetic medical enhancement and for therapeutic applications

摘要

The present invention relates to a biocompatible injectable filler composition comprising calcium phosphate particles having a porosity of about 10% to about 90%, a BET surface area of about 1 m2/g to about 100 m2/g, and a mean particle size of about 1 micron to about 30 microns, a thermoreversible hydrophilic gelling agent, a carrier comprising water and an optional persistence enhancer and/or volumizing agent, and methods of its use to restore tissue volume and/or to smooth out tissue defects as in soft tissue or deep tissue augmentation.

主权项

1. An injectable soft tissue filler composition comprising
(a) about 40% calcium phosphate particles, based on the weight of the filler composition, wherein the calcium phosphate particles have a porosity of about 10% to about 90%, a surface area of about 1 m2/g to about 100 m2/g, and a mean particle size of about 2 microns to about 10 microns, and are acid etched, (b) about 5% to about 15% poloxamer, based on the weight of the filler composition, wherein the poloxamer is a hydrogel that is in the form of a liquid at 25° C. and in the form of a gel having a viscosity of about 2000 cP or more at 35° C., (c) a persistence enhancer selected from the group consisting of dextran and agarose, and (d) aqueous carrier, wherein the soft tissue filler composition has a pH of about 6.5 to about 7.5, wherein the soft tissue filler composition can be injected through a 27 gauge or smaller opening needle, and wherein the soft tissue filler composition is pliable, moldable, flexible, and has a viscosity of about 100,000 cP to about 200,000 cP after injection into the soft tissue.