Method of using diketopiperazines and composition containing them

摘要

The invention provides a method of inhibiting the effects of platelet activating factor (PAF). For instance, a disease or condition mediated by PAF (particularly inflammation) can be treated or platelet aggregation can be inhibited. The invention also provides a method of inhibiting the production and/or release of interleukin 8 (IL-8) by cells. The effects of PAF and the production and/or release of IL-8 are inhibited according to the invention by a compound of the formula:;
wherein R1 and R2 are defined in the application, or a physiologically-acceptable salt thereof. The invention also provides pharmaceutical compositions comprising these compounds.

主权项

1. A method of treating psoriasis comprising administering to an animal in need thereof an effective amount of a compound of the formula:wherein:
R1 is —CH2COOH; and R2 is the side chain of alanine; or a physiologically-acceptable salt thereof.