Controlled-release floating pharmaceutical compositions

摘要

The invention relates to a pharmaceutical composition comprising a plurality of controlled-release coated microparticles each comprising a floating core, on the surface of which is deposited a layer containing at least one active principle, said layer being covered with a controlled-release coating, characterized by the fact that said floating core is composed of cellulose acetate phthalate and has an apparent density of less than or equal to 0.6 g/mL and said coated microparticles have a density of less than or equal to 0.7 g/mL.

主权项

1. A pharmaceutical composition comprising a plurality of controlled-release coated microparticles each comprising a floating core, on the surface of which is deposited a layer containing at least one active principle, without any intermediate layer, said layer containing at least one active principle being covered with a controlled-release coating,
wherein said floating core has a closed porosity greater than or equal to 0.2, wherein said floating core comprises cellulose acetate phthalate and does not comprise any active principle and has an apparent density of less than or equal to 0.6 g/mL and wherein said coated microparticles have an apparent density of less than or equal to 0.7g/mL.