| 发明名称 | Enhanced expression and stability regions | ||
| 摘要 | Expression-enhancing nucleotide sequences for expression in eukaryotic systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells. Enhanced expression and stability regions (EESYRs) are provided for expression of a gene of interest in a eukaryotic cell. Chromosomal loci, sequences, and vectors are provided for enhanced and stable expression of genes in eukaryotic cells. | ||
| 申请公布号 | US9562238(B2) | 申请公布日期 | 2017.02.07 |
| 申请号 | US201514967689 | 申请日期 | 2015.12.14 |
| 申请人 | REGENERON PHARMACEUTICALS, INC. | 发明人 | Chen Gang;Babb Robert;Fandl James P. |
| 分类号 | C12N15/85;C12N15/86;C12P21/02 | 主分类号 | C12N15/85 |
| 代理机构 | Scully, Scott, Murphy & Presser, P.C. | 代理人 | Scully, Scott, Murphy & Presser, P.C. ;Johnson Mary |
| 主权项 | 1. A method of making a recombinant cell comprising introducing at least one exogenous sequence into an expression-enhancing expression and stability region (EESYR) sequence, or 5′ or 3′ of an EESYR sequence, wherein the EESYR sequence is selected from the group consisting of SEQ ID NO:1-6. | ||
| 地址 | Tarrytown NY US | ||