Preparation method of organic microbubble complex particle, organic microbubble complex particle, and ultrasound contrast agent

摘要

This disclosure relates to a method for preparing organic microbubble complex particles including sonicating an aqueous solution including a graphene compound and an amphiphilic material in the presence of a gas, a method for preparing organic microbubble complex particles including injecting an aqueous solution including a graphene compound and an amphiphilic material into a microchannel, and an organic microbubble complex particle including a core part including at least one gas selected from the group consisting of an inert gas and carbon dioxide, and a shell layer including a graphene compound and an amphiphilic material, and an ultrasound contrast agent including the organic microbubble complex particles.

主权项

1. A method for preparing organic microbubble complex particles, comprising injecting an aqueous solution comprising a graphene compound and an amphiphilic material, and a gas, into a microchannel,
wherein the amphiphilic material includes a mixture of polyoxyethylene sorbitan fatty acid ester and sorbitan fatty acid ester mixed at a weight ratio of 1:5 to 5:1, and wherein the aqueous solution includes the graphene compound in a content of 0.001 to 0.1 parts by weight, based on 100 parts by weight of the amphiphilic material.