| 发明名称 |
Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders |
| 摘要 |
The present invention relates to compounds of formula I:;in which n, m, X, Y1, R1, R2, R3, R4 and R5 are defined in the Summary of the Invention; capable of being both potent antagonists and degraders of estrogen receptors. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with aberrant estrogen receptor activity. |
| 申请公布号 |
US9561211(B2) |
申请公布日期 |
2017.02.07 |
| 申请号 |
US201615066425 |
申请日期 |
2016.03.10 |
| 申请人 |
Novartis AG |
发明人 |
Burks Heather Elizabeth;Dechantsreiter Michael A.;He Guo;Nunez Jill;Peukert Stefan;Springer Clayton;Sun Yingchuan;Thomsen Noel Marie-France;Tria George Scott;Yu Bing |
| 分类号 |
A61K31/00;A61K31/381;C07D333/64;A61K31/4196;A61K31/422;A61K31/4245;A61K31/4436;A61K31/506;A61K45/06;C07D333/66;C07D409/12;C07D413/04;C07D413/12;C07D409/04;C07D409/10;C07D417/12;A61K31/397;A61K31/4025;A61K31/404;A61K31/41;A61K31/428;A61K31/5377 |
主分类号 |
A61K31/00 |
| 代理机构 |
|
代理人 |
Reid Scott W. |
| 主权项 |
1. A method of treating a cancer selected from breast, ovarian, endometrial, prostate, uterine, cervical and lung, comprising administering to a subject in need of such treatment an effective amount of a compound, or a pharmaceutically acceptable salt thereof, having the structure: |
| 地址 |
Basel CH |
