| 发明名称 | Method for improving the bioavailability of low aqueous solubility drugs | ||
| 摘要 | The present invention relates to the implementation of a new method for manufacturing solid dosage forms for oral administration comprising poorly water soluble active ingredients which overcomes the associated solubility problems and affords improved dissolution profile. | ||
| 申请公布号 | US9561186(B2) | 申请公布日期 | 2017.02.07 |
| 申请号 | US201214443094 | 申请日期 | 2012.11.30 |
| 申请人 | PHARMATHEN S.A. | 发明人 | Karavas Evangelos;Koutris Efthimios;Samara Vasiliki;Diakidou Amalia;Papanikolaou Georgia |
| 分类号 | A61K9/20;A61K31/40;A61K31/4535;A61K31/4985;A61K31/42;A61K47/22 | 主分类号 | A61K9/20 |
| 代理机构 | AKC Patents LLC | 代理人 | AKC Patents LLC ;Collins Aliki K. |
| 主权项 | 1. A pharmaceutical composition for oral administration comprising a poorly water soluble active ingredient, wherein the poorly water soluble active ingredient has a solubility of less than or equal to 0.1 mg/mL in water, and from about 15% to about 25% by weight of 2-pyrrolidone and from about 5% to about 15% by weight of silicon dioxide. | ||
| 地址 | Pallini, Attikis GR | ||