Titration method using a tracer to quantify the titrant

摘要

A titration method uses a tracer in the titrant or titrand to quantify the amount of titrant added. The method does not require quantitative addition of titrant or sample. The tracer can be inert or can participate as an indicator of the titrant-analyte reaction. If the tracer is inert, an alternative method for monitoring the progress of the titration is required. The tracer concentration is quantified by an appropriate method depending upon the type of tracer and analytical performance desired (e.g. precision, accuracy). The method simplifies titrations because it eliminates the need for a precision dispensing device and analytical balance.

主权项

1. A method of conducting a titration reaction wherein a tracer quantifies the relative proportions of titrant to titrand in the titration reaction, the method comprising the steps of:
a) placing the titrand solution comprising an analyte in a mixing vessel; b) adding an amount of titrant solution to the titrand solution, the titrant solution comprising the tracer of a concentration [tracer]T; c) mixing the titrant solution and titrand solution to obtain a homogeneous mixture; d) measuring the progress of the titrant reacting with the analyte with a detecting means; e) concurrently measuring a concentration of the tracer [tracer], with a tracer detecting means; f) determining a dilution factor wherein the dilution factor f is the ratio of total concentration of tracer in the titrant-titrand mixture  [tracertitrant]mix to tracer in the titrant [tracertitrant]T,fT=MTMmix=[tracertitrant]mix[tracertitrant]T=[titrant]mix[titrant]T  where MT is the amount of titrant added, Mmix is the quantity of the titrant-titrand mixture, [titrant]mix is the total titrant added to the titrand, and [titrant]T is the known concentration of titrant; and f) performing steps b)-e) until the titration is completed; g) performing steps b)-f) until the titration is completed; h) determining the concentration of the analyte in the titrand using the dilution factor, the measurement of the progress of the titration and a titration data analysis method,wherein the tracer is a chemical species that is not consumed or produced by the titration reaction, and wherein the concentration of the analyte in the titrand is determined without quantifying the volume of the added amount of titrant solution.