Compositions and methods for diagnosing or treating neutrophil-mediated inflammatory disease

摘要

Disclosed are nanoparticle compositions comprising nanoparticles prepared from denatured, cross-linked albumin and a therapeutic agent for treating a neutrophil-mediated inflammation, and methods of treating neutrophil-mediated inflammation using the compositions.

主权项

1. A method of delivering an agent to activated neutrophils comprising contacting the activated neutrophils with nanoparticles, each nanoparticle consisting of denatured, cross-linked albumin and the agent, the agent selected from a therapeutic agent and a detectable moiety, the nanoparticles selectively binding to and internalized by the activated neutrophils.