Ibuprofen for topical administration

摘要

Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl) propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skin tissue. Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e.g., a pyrrolidone solvent or dimethylacetamide.

主权项

1. A method of preparing a topical pharmacological composition that is physically and chemically stable, comprising the steps of:
(a) creating a first mixture by dissolving ibuprofen and potassium hydroxide in a solvent; (b) creating second mixture comprising at least one water soluble ingredient, wherein the at least one water soluble ingredient is L-arginine; (c) creating a third mixture comprising at least two hydrophobic ingredients, wherein one of the at least two hydrophobic ingredients is stearyl alcohol; (d) creating a fourth mixture by combining the second mixture and the third mixture; and (e) combining the first mixture and the fourth mixture to create the topical pharmacological composition that is physically and chemically stable.