发明名称 Nonaqueous backscattering interferometric methods
摘要 Disclosed are improved optical detection methods comprising multiplexed interferometric detection systems and methods for determining a characteristic property of a non-aqueous sample, together with various applications of the disclosed techniques.
申请公布号 US9562853(B2) 申请公布日期 2017.02.07
申请号 US201213402104 申请日期 2012.02.22
申请人 Vanderbilt University 发明人 Bornhop Darryl J.;Flowers Robert A.;Miller Esther Pesciotta
分类号 G01N21/45;G01N21/47 主分类号 G01N21/45
代理机构 Ballard Spahr LLP 代理人 Ballard Spahr LLP
主权项 1. A method for determining a characteristic property of a liquid sample comprising the steps of: a. providing an apparatus adapted for performing light scattering interferometry, the apparatus comprising i. a substrate; ii. a channel formed in the substrate capable of receiving the liquid sample to be analyzed; iii. a light source for generating a light beam; iv. a photodetector for receiving scattered light and generating intensity signals; and v. at least one signal analyzer capable of receiving the intensity signals and determining therefrom one or more characteristic properties of the liquid sample; and b. interrogating the liquid sample using backscattering interferometry, wherein the liquid sample comprises at least two binding partners in a solvent selected from ketone, aldehyde, alkane, chlorocarbon, sulfoxide, and acetonitrile, and wherein a molecular interaction between the binding partners is detected in the liquid sample via the interrogation.
地址 Nashville TN US