Carrier immunoglobulins

摘要

Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.

主权项

1. An isolated antigen binding protein comprising an immunoglobulin heavy chain variable region and an immunoglobulin light chain variable region, wherein the heavy chain variable region comprises three complementarity determining regions (CDRs) designated CDRH1, CDRH2 and CDRH3, and the light chain variable region comprises three CDRs designated CDRL1, CDRL2 and CDRL3, and wherein:
(a) CDRH1 comprises the amino acid sequence of SEQ ID NO:189; (b) CDRH2 comprises the amino acid sequence of SEQ ID NO:193; (c) CDRH3 comprises the amino acid sequence of SEQ ID NO:198; (d) CDRL1 comprises the amino acid sequence of SEQ ID NO:203; (e) CDRL2 comprises the amino acid sequence of SEQ ID NO:206; and (f) CDRL3 comprises the amino acid sequence of SEQ ID NO:209.