| 主权项 |
1. A self-assembled cage-like (SAGE) particle comprising a plurality of first hubs and a plurality of second hubs, wherein:
i. each of the first hubs comprises a core comprising a trimeric, tetrameric or hexameric coiled coil peptide structure, wherein the core of each first hub is linked to at least 3 first peptides, wherein each first peptide is capable of interacting with a second peptide to form a dimeric coiled coil structure; and ii. each of the second hubs comprises a core comprising a trimeric, tetrameric or hexameric coiled coil peptide structure, wherein the core of each second hub is linked to at least 3 second peptides, wherein each second peptide is capable of interacting with a first peptide to form a dimeric coiled coil structure, wherein first hubs and second hubs interact by the formation of dimeric coiled core structures between first and second peptides, forming a network which closes to form a sphere with a hollow core and surface pores, wherein the core of each of the first and second hubs is selected from the group consisting of
a homotrimeric coiled coil structure wherein each peptide of the trimeric coiled structure comprises SEQ ID NO: 1, 7, 15, or 16,a homotetrameric coiled coil structure wherein each peptide of the tetrameric coiled structure comprises SEQ ID NO: 2,a hexameric coiled coil structure wherein three of the peptides of the hexameric structure comprise SEQ ID NO: 10, and the other three peptides comprise SEQ ID NO: 11, anda heterotrimeric coiled coil structure wherein a peptide comprising SEQ ID NO: 12, a peptide comprising SEQ ID NO: 13, and a peptide comprising SEQ ID NO: 14 form the structure, andwherein each of the dimeric coiled coil structures are formed by a pair of first and second peptides selected from the group consisting of
a second peptide comprising SEQ ID NO: 3 and a second peptides comprising SEQ ID NO: 4,a first peptide comprising SEQ ID NO: 5 and a second peptide comprising SEQ ID NO: 6.a first peptide comprising SEQ ID NO: 3 and a second peptide comprising SEQ ID NO: 17, anda first peptide comprising SEQ ID NO: 8 and a second peptide comprising SEQ ID NO: 9. |
