| 主权项 |
1. A vessel flow control device for controlling at least one of a flow rate or a pressure within a lumen of a vessel of a mammalian patient during a treatment of an afflicted region of the vessel, the lumen including a cross-sectional area, the device comprising:
a variable occlusion element configured for placement within the lumen and to assume a plurality of occlusion states within the lumen, each occlusion state including an occlusion factor ranging from about five percent to about one hundred percent, wherein the occlusion factor is a percentage of the lumen cross-sectional area occluded by a cross-sectional area of the variable occlusion element and an occlusion factor of one hundred percent corresponds to a complete blockage of flow through the vessel; a mechanism configured to receive a plurality of inputs to cause the variable occlusion element to selectively transition between the plurality of occlusion states such that a subsequent occlusion state has: a lower occlusion factor than a current occlusion state based on a measurement of vascular leakage in the afflicted region indicating no vascular leakage; and a higher occlusion factor than the current occlusion state based on the measurement of vascular leakage in the afflicted region indicating vascular leakage, each of the received plurality of inputs comprising a control signal to actuate the mechanism to cause the variable occlusion element to transition from the current occlusion state to the subsequent occlusion state; and a feedback control system comprising at least one processor and a computer readable medium comprising instructions that, when executed by the at least one processor, cause the feedback control system to receive multiple measurements of vascular leakage and to generate the plurality of inputs to cause the variable occlusion element to selectively transition between the plurality of occlusion states based on the multiple measurements of vascular leakage. |
