Methods for making oxidation resistant polymeric material

摘要

The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.

主权项

1. A method of making a hybrid material comprising oxidation and wear resistant, cross-linked polymeric material containing detectable free radicals, wherein the method comprises:
a) blending polymeric material with an antioxidant in the absence of a supercritical fluid; b) consolidating the antioxidant blended polymeric material to another piece, thereby forming an interface and an interlocked hybrid material; c) irradiating the interlocked hybrid material by ionizing radiation, thereby forming a hybrid material comprising oxidation and wear resistant, cross-linked polymeric material containing detectable free radicals; and d) annealing the oxidation and wear resistant, cross-linked hybrid material in a liquid environment.