| 发明名称 | Low-burst polymers and methods to produce polymer | ||
| 摘要 | A PLG copolymer material, termed a PLG(p) copolymer material, adapted for use in a controlled release formulation for a bioactive material is provided, wherein the formulation exhibits a reduced “initial burst” effect when introduced into the tissue of a patient in need thereof. A method of preparation of the PLG copolymer material is also provided, as are methods of use. | ||
| 申请公布号 | US9561282(B2) | 申请公布日期 | 2017.02.07 |
| 申请号 | US201514924243 | 申请日期 | 2015.10.27 |
| 申请人 | Tolmar Therapeutics, Inc. | 发明人 | Dadey Eric;Middleton John;Norton Richard L. |
| 分类号 | A61K47/34;A61K38/08;A61K38/12;C08G63/08;C08G63/90;A61K9/00 | 主分类号 | A61K47/34 |
| 代理机构 | Sheridan Ross, P.C. | 代理人 | Sheridan Ross, P.C. |
| 主权项 | 1. A controlled release formulation comprising a flowable delivery system comprising: an organic solvent, a bioactive agent and a biocompatible, biodegradable, non-hydrolyzed linear PLG low-burst copolymer material having a weight average molecular weight of about 15 kilodaltons to about 50 kilodaltons and a polydispersity index of about 1.4 to about 1.8 and which low-burst linear copolymer material is free of a copolymer fraction characterized by a weight average molecular weight of about 4 kDa to about 10 kDa and a polydispersity index of about 1.4 to 2.5. | ||
| 地址 | Fort Collins CO US | ||