Moléculas de anticuerpo que tienen especificidad por el factor de necrosis tumoral alfa humano y sus usos

摘要

There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF±. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF±.