Method for estimating changes of cardiovascular indices using peripheal arterial blood pressure waveform

摘要

The systems and methods described herein enable reliable estimation of cardiovascular indices on real-time, non-invasive or minimally-invasive, and beat-to-beat basis. Cardiovascular indices which can be estimated include: stroke volume (SV), which being limited to, cardiac output (CO) and total peripheral resistance (TPR). In various embodiments, one or more of these indices are estimated continuously, on a beat-to-beat basis, using peripheral arterial blood pressure (ABP) waveforms and certain parameters derived from the peripheral ABP waveforms. The derived parameters are substantially insensitive to distortions of the ABP waveform arising from tapered arterial branches throughout the arterial tree. The methods describe herein can provide a more accurate and reliable estimate of hemodynamic parameters than existing techniques.

主权项

1. A method performed on a computer for estimating stroke volume of a cardiac cycle of a heart comprising:
a. recording an arterial blood pressure signal; b. processing with the computer the arterial blood pressure signal to obtain five parameters which are insensitive to distortions resulting from propagation of an arterial pulse through an arterial tree; the five parameters consisting of mean arterial pressure of a cardiac cycle, end-diastolic pressure of the cardiac cycle, end-diastolic pressure of an immediately preceding cardiac cycle, duration of the cardiac cycle and duration of systole of the cardiac cycle; c. incorporating only the five parameters into a formula or algorithm to estimate with the computer the stroke volume of the cardiac cycle of the heart; d. estimating with the computer the stroke volume from the formula or algorithm; and e. outputting the estimated stroke volume from the computer and f. wherein the method further comprises estimating a characteristic time constant of the cardiac cycle and the method further includes determining coefficients associated with the formula or algorithm by analyzing a training set of arterial blood pressure signal data for which the associated stroke volumes have been independently measured.