发明名称 |
SIRP-ALPHA VARIANT CONSTRUCTS AND USES THEREOF |
摘要 |
The invention relates to compositions and methods of SIRP-a variant constructs including SIRP-.alpha. variants. The SIRP-.alpha. variant constructs may be engineered in a variety of ways to respond to environmental factors, such as pH, hypoxia, and/or the presence of tumor-associated enzymes or tumor-associated antigens. The SIRP-.alpha. variant constructs of the invention may be used to treat various diseases, such as cancer, preferably solid tumor or hematological cancer. |
申请公布号 |
CA2938180(A1) |
申请公布日期 |
2017.02.07 |
申请号 |
CA20162938180 |
申请日期 |
2016.08.04 |
申请人 |
ALEXO THERAPEUTICS INC. |
发明人 |
DEMING, LAURA;GOODMAN, COREY;PONS, JAUME;SIM, BANG JANET;VRLJIC, MARIJA |
分类号 |
C07K14/705;C07K14/47;C07K14/765;C07K16/28;C07K17/08;C07K19/00;C12N15/12;C12N15/62;C12P21/02 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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