| 发明名称 | Bispecific antibody | ||
| 摘要 | Provided are bispecific antibodies comprised of a single-chain unit having specificity to an immune cell and a monovalent unit having specificity to a tumor cell or a microorganism. The single-chain unit includes a single-chain variable fragment (scFv) fused to an Fc fragment and the monovalent unit includes a light chain and heavy chain pair. Also provided are methods of preparing bispecific antibodies and pharmaceutical and diagnostic uses of these antibodies. | ||
| 申请公布号 | US9562110(B2) | 申请公布日期 | 2017.02.07 |
| 申请号 | US201214119179 | 申请日期 | 2012.11.21 |
| 申请人 | Wuhan YZY Biopharma Co., Ltd. | 发明人 | Zhou Pengfei;Zhang Jing;Yan Yongxiang |
| 分类号 | C07K16/46;C07K16/32;C07K16/28 | 主分类号 | C07K16/46 |
| 代理机构 | Sheppard Mullin Richter & Hampton LLP | 代理人 | Sheppard Mullin Richter & Hampton LLP |
| 主权项 | 1. An antibody comprising: (a) a monovalent unit comprising a light chain-heavy chain pair having specificity to a tumor antigen selected from the group consisting of EGFR, Her2, EpCAM, CD20, CD30, CD33, CD47, CD52, CD133, CEA, gpA33, Mucins, TAG-72, CIX, PSMA, folate-binding protein, GD2, GD3, GM2, VEGF, VEGFR, Integrin, αVβ3, α5β1, ERBB2, ERBB3, MET, IGF1R, EPHA3, TRAILR1, TRAILR2, RANKL, FAP and Tenascin, wherein the heavy chain comprises a human or a humanized IgG1 Fc fragment; and (b) a single-chain unit comprising SEQ ID NO: 1 having specificity to CD3. | ||
| 地址 | Wuhan CN | ||