| 发明名称 | Gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7p15-21 and uses thereof | ||
| 摘要 | The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance. | ||
| 申请公布号 | US9561264(B2) | 申请公布日期 | 2017.02.07 |
| 申请号 | US201313938938 | 申请日期 | 2013.07.10 |
| 申请人 | The Brigham and Women's Hospital, Inc. | 发明人 | Frank Markus H.;Sayegh Mohamed H. |
| 分类号 | A61K38/17;A61K39/00;A61K39/395;C07K16/28;C07K14/705;A61K38/00;A61K48/00 | 主分类号 | A61K38/17 |
| 代理机构 | Wolf, Greenfield & Sacks, P.C. | 代理人 | Wolf, Greenfield & Sacks, P.C. |
| 主权项 | 1. An isolated monoclonal antibody specific for a 7p15-21 P-glycoprotein, wherein the 7p15-21 P-glycoprotein comprises SEQ ID NO:1, SEQ ID NO:2, or SEQ ID NO:3 and wherein the antibody selectively binds to SEQ ID NO:1, SEQ ID NO:2, or SEQ ID NO:3. | ||
| 地址 | Boston MA US | ||