发明名称 |
formulações de liberação prolongada para entrega de proteínas ao olho e métodos de preparar as mesmas |
摘要 |
The present invention provides for injectable pharmaceutical sustained release formulations for delivery of active agents, particularly therapeutic proteins, to the eye. The formulations are biocompatible, biodegradable sustained release formulations comprising low-solubility liquid excipients and relatively small amounts (less than about 10%) of biocompatible, biodegradable polymer such as PLA or PLGA polymers. A unit dose of 5 μL to 100 μL of the formulation provides for sustained release of the agent for at least 14 days. |
申请公布号 |
BR112013031685(A2) |
申请公布日期 |
2017.02.07 |
申请号 |
BR20131131685 |
申请日期 |
2012.06.11 |
申请人 |
ICON BIOSCIENCE, INC.;RAMSCOR, INC |
发明人 |
GLENN T. HUANG;LOUIS L. WOOD;VERNON G. WONG |
分类号 |
A61K9/08;A61K39/395;A61K47/30;A61P27/02 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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