Use of anti-CD83 agonist antibodies for treating autoimmune diseases

摘要

This invention relates to compositions comprising anti-CD83 agonist antibodies and methods of treating autoimmune disorders (such as inflammatory bowel disease) with anti-CD83 agonist antibodies, as well as articles of manufacture comprising anti-CD83 agonist antibodies.

主权项

1. A method for treating an autoimmune disease in an individual comprising administering to the individual an effective amount of an anti-CD83 agonist antibody, wherein the autoimmune disease is selected from the group consisting of multiple sclerosis, ulcerative colitis, inflammatory bowel disease, Crohn's disease, psoriasis, vasculitis, and diabetes mellitus, and wherein the anti-CD83 agonist antibody has one or more of the following characteristics: inhibits release of a pro-inflammatory cytokine from mature dendritic cells, induces release of an anti-inflammatory cytokine from mature dendritic cells, induces a decrease of cell surface expression of CD83 and/or HLA-DR on mature dendritic cells, and inhibits activation of MAPK and/or mTOR signaling in mature dendritic cells.