| 发明名称 | Co-encapsulation of live cells with oxygen-generating particles | ||
| 摘要 | Microcapsules are described that comprise (a) a liquid aqueous or hydrogel core; (b) a semipermeable membrane surrounding said core; (c) live animal cells (e.g., pancreatic cells) in the core; and (d) oxygen-generating particles in said core, said oxygen-generating particles included in said microcapsules in an amount sufficient to lengthen the duration of viability of said animal cells in said microcapsules. Compositions comprising such microcapsules and uses thereof, such as in treating diabetes, are also described. | ||
| 申请公布号 | US9561254(B2) | 申请公布日期 | 2017.02.07 |
| 申请号 | US201615183037 | 申请日期 | 2016.06.15 |
| 申请人 | Wake Forest University Health Sciences | 发明人 | Opara Emmanuel C.;Harrison Benjamin S. |
| 分类号 | A61K35/39;A61K9/50;A61K47/42;A61K47/02;A61K47/22;A61K38/18;C12N1/04 | 主分类号 | A61K35/39 |
| 代理机构 | Myers Bigel, P.A. | 代理人 | Myers Bigel, P.A. |
| 主权项 | 1. A microcapsule comprising: (a) a liquid aqueous or hydrogel core; (b) a semipermeable membrane surrounding said core; (c) live mammalian pancreatic islet cells in said core; and (d) oxygen-generating particles in said core, said oxygen-generating particles included in said microcapsules in an amount sufficient to lengthen the duration of viability of said mammalian animal cells in said microcapsules wherein said oxygen-generating particles are inorganic peroxides selected from the group consisting of calcium peroxide, magnesium peroxide, sodium peroxide, sodium percarbonate, benzylperoxide, and combinations thereof. | ||
| 地址 | Winston-Salem NC US | ||