Methods and devices for delivering agents across biological barriers

摘要

The invention provides for microneedle devices for delivering agents across biological barriers. The microneedles include agent reservoirs integrated into the bodies of the microneedles, themselves.

主权项

1. A device for delivering an agent across a biological barrier comprising:
a first microneedle comprising an integrated first reservoir which is an opening through the entirety of the width of the first microneedle and which comprises an agent stored in a dried or semi-solid state; a first base element from which the first microneedle extends; a substrate to which the first base element is coupled; and a first depth guard that extends from the substrate and around a portion of the microneedle; wherein a predetermined volume of the agent is contained predominantly within the interior volume of the microneedle; and wherein the first microneedle, the substrate and the first depth guard are a monolithic single unit.