发明名称 |
Procedimientos y composiciones para el enriquecimiento basado en metilación de ácido nucleico fetal de una muestra materna útiles para diagnósticos prenatales no invasivos |
摘要 |
Provided is a method for determining the amount of fetal nucleic acid in a sample comprising: a) contacting nucleic acid present in a sample from a pregnant female, which sample comprises differentially methylated fetal nucleic acid and maternal nucleic acid, with an agent that specifically binds methylated nucleotides; thereby producing bound nucleic acid; b) isolating the bound nucleic acid of (a), thereby enriching the fetal nucleic acid; and c) determining the amount of fetal nucleic acid by analyzing the amount of fetal nucleic acid of (b) at a plurality of loci selected from loci of SEQ ID NOs:1-89. |
申请公布号 |
ES2599967(T3) |
申请公布日期 |
2017.02.06 |
申请号 |
ES20090815148T |
申请日期 |
2009.09.16 |
申请人 |
Sequenom, Inc.;Sequenom Center For Molecular Medicine |
发明人 |
EHRICH, Mathias;NYGREN, Anders |
分类号 |
C12N15/10;C12N15/11;C12Q1/68 |
主分类号 |
C12N15/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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