PHENANTHROLINE PHOSPHONIC ACID DERIVATIVE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

摘要

The present invention relates to a novel phenanthroline phosphonic acid compound and a pharmaceutical salt thereof, as well as an application of the compound and the pharmaceutical salt thereof as collagen prolyl hydroxylase inhibitors in the preparation of drugs for preventing or treating collagen prolyl-4-hydroxylase related disease.

主权项

1. A compound of formula (I) or formula (II),
or a pharmaceutically acceptable salt thereof: wherein: X is —Cl or —OR3; wherein, R3 is selected from —H, —C(O)—(C1-C6 alkyl), —PO(OH)2 and —CH2OPO(OH)2;
R1 and R2 can be independently selected from H, C1-C6 alkyl, —CH2OCO—(C1-C6 alkyl) and —CH2OCOO—(C1-C6 alkyl); or R1 and R2 join to form a group having the formula: wherein, Y is aryl or heteroaryl; wherein: Z is selected from —H, and —CH2OPO(OH)2;
R1 and R2 can be independently selected from H, C1-C6 alkyl, —CH2OCO—(C1-C6 alkyl) and —CH2OCOO—(C1-C6 alkyl); or R1 and R2 join to form a group having the formula: Wherein, Y is aryl or heteroaryl.