ANIMAL MODELS OF AGE-RELATED DISORDERS AND AGE-SENSITIVE TRAITS ASSOCIATED WITH SENESCENCE-INDUCING STIMULI AND USES THEREOF

摘要

This disclosure provides non-human animal models for age-related disorders and age-sensitive traits, particularly those caused by senescence-inducing stimuli, wherein the models comprise transgenes selectively expressed by senescent cells. The disclosure further provides methods for identifying therapeutic agents effective for treating or preventing age-related disorders and age-sensitive traits using the animal models, therapeutic agents identified using such methods, pharmaceutical compositions comprising the identified therapeutic agents, and methods of treating or preventing age-related disorders and age-sensitive traits.

主权项

1. A non-human animal model for aging comprising a non-human animal that (a) exhibits an age-related disorder or age-sensitive trait, and (b) comprises a transgene selectively expressed by senescent cells, wherein the animal is exposed to or treated with a senescence-inducing stimulus.