DIAGNOSIS OF CHRONIC KIDNEY DISEASE BY QUANTITATIVE ANALYSIS OF POST-TRANSLATIONAL MODIFICATIONS OF PLASMA PROTEINS

摘要

The present invention relates to methods for diagnosing and/or monitoring the onset or progression of chronic kidney disease (CKD) in a patient by the analysis of post-translational modification of plasma proteins. The present invention provides improved means for diagnosing chronic kidney disease (CKD), and especially for the early recognition of CKD.

主权项

1. A method for diagnosing or monitoring pre-disease state or early stage chronic kidney disease (CKD) in an individual, the method comprising:
(a) analyzing in vitro the pattern of posttranslational modifications of a plasma protein of an individual to be diagnosed, wherein, if the plasma protein is LDL, the posttranslational modification is not carbamylation, and wherein, if the plasma protein is haemoglobin, the posttranslational modification is not carbamylation or oxidation; (b) comparing the posttranslational modification pattern of the plasma protein of the individual to be diagnosed with the posttranslational modification pattern of the plasma protein of an individual not suffering from CKD; and (c) detecting a difference in the posttranslational modification pattern of the plasma protein of the individual to be diagnosed as compared to the posttranslational modification pattern of the plasma protein from the individual not suffering from CKD.