PROTECTIVE EFFECT OF DMPC, DMPG, DMPC/DMPG, EGPG, LYSOPG AND LYSOPC AGAINST DRUGS THAT CAUSE CHANNELOPATHIES

摘要

The present invention includes compositions and methods for preventing one or more cardiac channelopathies or conditions resulting from irregularities or alterations in cardiac patterns caused by an active agent or a drug in a human or animal subject comprising: an amount of a lysophosphatidyl compound adapted for oral administration effective to reduce or prevent one or more cardiac channelopathies or conditions resulting from irregularities or alterations in cardiac patterns caused by the active agent or drug. Such compositions may further comprise a monoglyceride, a free fatty acid or a combination of the foregoing, including, e.g., a eutectic mixture. WO 2015/187883 PCT/US2015/034078 . 1.00 - .. Nilotinib, 0.1 pM 0.40 ::'DMPC + Nilotinib, 0.1 pM Baseline 0.60 * e ' ..-Nilotinib, 0.1 pM DMPG + Nilotinib, 0.1 pM 0.40 0.00- ------- ,------------ Baseline