| 发明名称 |
Immunoglobulins Binding Human Vgamma9 Vdelta2 T Cell Receptors |
| 摘要 |
The invention is in the field of medicine and relates to immunology, and relates in particular to human Vγ9Vδ2 T cell receptor binding immunoglobulin molecules. Human Vγ9Vδ2 T cell receptor binding immunoglobulin molecules are in particular for use in medical treatment and/or useful in assays with human Vγ9Vδ2 T cells, wherein human Vγ9Vδ2 T cells may be modulated. |
| 申请公布号 |
US2017029506(A1) |
申请公布日期 |
2017.02.02 |
| 申请号 |
US201515302927 |
申请日期 |
2015.04.10 |
| 申请人 |
Stichting VUmc |
发明人 |
VAN DER VLIET Johannes Jelle;DE BRUIN Renée Cornelia Gerarda;DE GRUIJL Tanja Denise;VERHEUL Hendrik Marinus Willem |
| 分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A human Vγ9Vδ2 T cell receptor binding immunoglobulin molecule, comprising a CDR1 region and a CDR 2 region,
wherein the CDR1 region comprises an amino acid sequence with at least 40% sequence identity with the amino acid sequence of SEQ ID NO. 31 GRTFSNYAMG, and wherein the CDR2 region comprises an amino acid sequence with at least 60% sequence identity with the amino acid sequence of SEQ ID NO. 32 AISWSGGSTYYADSVKG; and wherein preferably the immunoglobulin molecule is a single chain antibody. |
| 地址 |
Amsterdam NL |
