发明名称 |
DRUG COMPOSITION AND METHOD FOR PREPARING THE SAME |
摘要 |
The present invention provides a method for preparing a drug composition, which includes steps of dispersing an amphiphilic chitosan derivative, at least a hydrophobic drug, and at least a hydrophilic drug into a solvent to form a mixture solution, and the pH value of the mixture solution is adjusted to a range without precipitating the hydrophilic drug(s) and the hydrophobic drug(s), wherein the amphiphilic chitosan derivative is modified by a plurality of hydrophilic group(s) and a plurality of hydrophobic group(s); and after stirring the mixture solution for at least 12 hours, receiving the drug composition when the pH value of the mixture solution is between pH 6 to 7. The hydrophilic drug(s) and the hydrophobic drug(s) are encapsulated simultaneously by one-pot synthesis, and the protein could be modified by one-pot synthesis to provide a drug composition with multiple functions. |
申请公布号 |
US2017027877(A1) |
申请公布日期 |
2017.02.02 |
申请号 |
US201514934519 |
申请日期 |
2015.11.06 |
申请人 |
National Chiao Tung University |
发明人 |
Huang Wei-Ting;Lee Yi-Chi;Liu Dean-Mo |
分类号 |
A61K9/51;A61K47/48;A61K47/36;A61K33/24;A61K31/12 |
主分类号 |
A61K9/51 |
代理机构 |
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代理人 |
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主权项 |
1. A preparation method of a drug composition, comprising:
dispersing an amphiphilic chitosan derivative, at least a hydrophobic drug, and at least a hydrophilic drug in an solvent to form a mixture solution, wherein the amphiphilic chitosan derivative is modified with a plurality of hydrophilic groups and a plurality of hydrophobic groups, and the pH of the mixture solution is adjusted to a range without precipitating the hydrophilic drug and the hydrophobic drug; and after stirring the mixture solution for at least 12 hours, receiving the drug composition when the pH of the mixture solution is between 6 to 7. |
地址 |
Hsinchu TW |