发明名称 |
1,3,4-OXADIAZOLE AMIDE DERIVATIVE COMPOUND AS HISTONE DEACETYLASE 6 INHIBITOR, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME |
摘要 |
The present invention relates to: a novel compound having a histone deacetylase 6 (HDAC6) inhibitory activity; an optical isomer thereof or a pharmaceutically acceptable salt thereof; a use thereof for preparing a therapeutic pharmaceutical preparation; a pharmaceutical composition containing the same and a treatment method using the composition; and a preparation method therefor. According to the present invention, the novel compound and the optical isomer thereof or pharmaceutically acceptable salt thereof have histone deacetylase 6 (HDAC6) inhibitory activity and are effective in preventing or treating HDAC6-associated diseases including: infectious diseases; neoplasm; endocrine, nutritional and metabolic diseases; psychological and behavioral disorders; neurological disorders; eye and adnexa diseases; circulatory system diseases; respiratory system diseases; digestive system diseases; skin and subcutaneous tissue diseases; musculo-skeletal system and connective tissue diseases; or congenital malformations, deformations and chromosomal abnormalities. |
申请公布号 |
WO2017018804(A1) |
申请公布日期 |
2017.02.02 |
申请号 |
WO2016KR08216 |
申请日期 |
2016.07.27 |
申请人 |
CHONG KUN DANG PHARMACEUTICAL CORP. |
发明人 |
LEE, Jaekwang;KO, Moo Sung;HAN, Younghue;KIM, Yuntae |
分类号 |
C07D271/10;A61K31/4245;C07D413/10;C07D413/12 |
主分类号 |
C07D271/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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