摘要 |
The present invention relates to a novel double-stapled peptide and, more particularly, to a double-stapled peptide and an antimicrobial or anticancer composition containing the same. The double-stapled peptide according to the present invention can effectively stabilize a peptide into a helical secondary structure by the double introduction of staples. In addition, the peptide, of which the secondary structure is stabilized in a helical form by the staples, has high stability against a protease since the protease cannot recognize a helical peptide as a substrate. In addition, in a helical structure obtained by stapling, positively charged amino acids are arranged at the opposite position of hydrophobic staples so as to form an amphipathic helical structure, such that an antimicrobial activity is exhibited by destroying bacterial cell walls as many antimicrobial peptides existing in nature exhibit. Therefore, the double-stapled peptide according to the present invention can be used for various purposes and uses requiring an antimicrobial activity and, additionally, is expected to be usable in an anticancer composition. |