| 摘要 |
The present invention is to provide a novel compound (I) shown below, having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof.;;(wherein
Z1 is NR4;R1 is hydrogen or lower alkyl;X is a single bond, a hetero atom group selected from O, S, SO, SO2 and NH, or lower alkylene or lower alkenylene in which the hetero atom group may intervene;R2 is optionally substituted aryl;R3 is hydrogen, a halogen, hydroxy, optionally substituted lower alkyl etc; andR4 and Z2 part taken together forms a ring, to form a polycyclic compound, including e.g., a tricyclic or tetracyclic compound. |
